Marnie Weber was born in Bridgeport, Connecticut, U.S.. She studied at the University of Southern California, Los Angeles, CA, and received her B.A. from University of California, Los Angeles.

Much of Weber's visual art revolves around a recurring cast of characters. An animal often found in her work is the bear, which is linked to the Greek goddess Artemis.These characters, among others, are placed in "vividly colorful environments",ornate, Empire style interiors or dark, dense, eerie landscapes. Her work most often focuses on the adventures of women, which sometimes take the form of half-human, half-animal hybrids with bodies cut from pornographic magazines, and other times, pale-faced, folksy ghosts known as "Spirit Girls".